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pentobarbital will decrease the extent or result of darunavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital decreases levels of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with potent CYP3A4 inducers; these medications minimize exposure to